Plasma S100β is not a useful biomarker for tumor burden in neurofibromatosis

Erratum: Plasma neurofilament heavy chain is not a useful biomarker in Charcot-Marie-Tooth disease.

INTRODUCTION The negative results in trials of vitamin C in Charcot-Marie-Tooth disease (CMT) type 1A have highlighted the lack of sensitive outcome measures. Neurofilaments are abundant neuronal cytoskeletal proteins, and their concentration in blood is likely to reflect axonal breakdown. We therefore examined plasma neurofilament heavy-chain (NfH) concentration as a potential biomarker in CMT...

Soluble AXL: A Possible Circulating Biomarker for Neurofibromatosis Type 1 Related Tumor Burden

Neurofibromatosis type 1 (NF1) is the most common tumor predisposition disorder affecting 1/3500 worldwide. Patients are at risk of developing benign (neurofibromas) and malignant peripheral nerve sheath tumors (MPNST). The AXL receptor tyrosine kinase has been implicated in several kinds of cancers, but so far no studies have investigated the role of AXL in NF1 related tumorigenesis. Recently,...

S100β: A Predictive Biomarker for Neural Trauma with Therapeutic Potential

for making both diagnoses and prognoses of neurological injury. Of the more than 20 isoforms in the S100 protein family, S100ß displays unique biomarker and diagnostic properties in ectodermic derived normal neurons and certain malignancies. The purpose of this focused review is to highlight and discuss findings that support the notion that S100ß can be used as a biomarker to indicate the prese...

Plasma Osteopontin Is a Useful Diagnostic Biomarker for Advanced Non-Small Cell Lung Cancer

BACKGROUND Osteopontin (OPN) and carbonic anhydrase IX (CAIX), which are expressed on the surface of tumor cells, are associated with hypoxia during tumor development and progression. However, the roles of these proteins in the plasma of patients with non-small cell lung cancer (NSCLC) are poorly understood. Herein, we hypothesized that plasma OPN and CAIX levels could be used as diagnostic and...

serum leptin in peritoneal dialysis: is it a useful biomarker following peritonitis?